Multiple death pathways in TNF-treated fibroblasts:RIP3-and RIP1-deoendent and independent routes
@@ Dear Editor,Tumor necrosis factor-α(TNF)can induce either apoptosis or programmed necrosis(necroptosis)when different cell lines are used”1,2”.While receptorinteracting protein 1(RIPI)can participate in signaling for both apoptosis and necrosis”3,4”,recent studies by us and by others have shown that RIP3 is essential for TNF-induced necroptosis”5-7” and has no role in TNFinduced poptosis”6,7”.Classification of TNF-induced cell death in a number of cell lines,such as L929 and murine embryonic fibroblasts(MEFs),has been made based on morphological and/or biochemical parameters ”2,7-10”.
cell death、cell lines、TNF、essential、different、studies、based、made
21
Q2(细胞生物学)
973 program2009CB522200;111 ProjectB06016;NSFC30830092;CPSF20100470040
2011-04-27(万方平台首次上网日期,不代表论文的发表时间)
368-371