The GTPase-activating protein Rap1GAP: A new player to modulate Ret signaling

摘要：

@@ Glial cell line-derived neurotrophic factor (GDNF) plays a critical role in orchestrating the development and maintenance of different populations of central and peripheral neurons. GDNF was initially discovered by its abil-ity to promote the survival of ventral midbrain dopaminergic neurons ”1”. In addition, GDNF promotes the survival and control the differentiation of motor neurons and many peripheral neurons, including sensory and sympathetic neu- rons. Moreover, it is required to induce proliferation, migration and survival of enteric neurons. GDNF promotes these trophic effects through the activation of the receptor tyrosine kinase (RTK) Ret.

机标关键词：Rap1GAP、Ret、player、survival、dopaminergic neurons、neurotrophic factor、GDNF、tyrosine kinase、motor neurons、maintenance、development、migration、different、required、receptor、addition、promote、control、central、plays

所属期刊栏目：21

分类号：Q2(细胞生物学)

在线出版日期：2011-04-27（万方平台首次上网日期，不代表论文的发表时间）

页码：217-219