Taming of macrophage and microglial cell activation by microRNA-124

摘要：

@@ Microglial cells are from the myeloid lineage and are the only hematopoietic cell resident to the central nervous sys-tem (CNS). They populate the CNS during development and are located throughout the CNS. In the adult, micro-glial cells are maintained in a quiescent state exhibiting a ramified morphology.These resting microglial cells are char-acterized by a CD45lo phenotype and express very low levels of the antigen presentation molecules MHC class Ⅱ, B7.2 and CD40 ”1”. Although quiescent, microglial cells are dynamic constantly sending out processes to survey their surrounding microenvironment ”2”.Upon encounter with activation signals, microglial cells are able to rapidly respond by changing both morphologi-cally and phenotypicaily.

机标关键词：cells、development、processes、MHC class、CNS、changing、express、dynamic、central、survey、levels、during、CD40、B7.2

所属期刊栏目：21

分类号：Q2(细胞生物学)

在线出版日期：2011-04-27（万方平台首次上网日期，不代表论文的发表时间）

页码：213-216