IDH1 mutant structures reveal a mechanism of dominant inhibition
@@ Pioneered by a major cancer genome sequencing project ”1” and followed by numerous cancer genomic sequencing studies ”2-4”, the cytosolic isocitrate dehydrogenase (IDH1) gene and mitochondria isocitrate dehydrogenase (IDH2) gene are found to be frequently mutated in low grade gliomas and secondary glioblastoma multiforme (GBM), acute myeloid leukemia (AML), and to a much lower frequency in other types of tumors.
myeloid leukemia、studies、major、found、GBM、AML
20
Q2(细胞生物学)
2011-01-14(万方平台首次上网日期,不代表论文的发表时间)
1279-1281