IкBβ is a positive and negative regulator of NF-кB activity during inflammation
@@ Nuclear factor кB (NF-кB) transcription factors play key roles in many physiological processes including immune responses and inflammation. The NF-кB family consists of p65, cRel, RelB, p50 and p52, which form dimers and bind to кB sites in the promoters of target genes ”1”. Among them, p65, cRel and RelB have a transactivating domain (TAD) and induce transcription by recruiting transcriptional co-activators. p50 and p52 lack a TAD and thus suppress or stimulate transcription in a context-specific manner.
negative、positive、immune responses、processes、RelB、factors、p50、family、domain、lack、form、key
20
Q2(细胞生物学)
2010-12-31(万方平台首次上网日期,不代表论文的发表时间)
1178-1180