Not miR-ly aging: SIRT1 boosts memory via a microRNA-dependent mechanism
@@ Long-term memory formation requires new synthesis of proteins that regulate synaptic plasticity. Recently, microRNAs (miRNAs) have been identified as master regulators of protein synthesis, miRNAs are an extensive class of small noncoding RNAs (21-25 nt) that preferentially bind to the 3” untranslated regions (UTRs) of mRNAs,thereby either inducing translational repression or degradation of the target mRNA. In the nervous system, miRNAs control diverse processes, ranging from specification of neuronal cell identity to synaptic plasticity ”1”.
via、memory、protein synthesis、miRNAs、nervous system、neuronal cell、processes、identity、control、small、mRNAs、class、new
20
Q2(细胞生物学)
2010-12-31(万方平台首次上网日期,不代表论文的发表时间)
1175-1177