Silkworm(Bombyx mori)BmLid is a histone lysine demethylase with a broader specificity than its homolog in Drosophila and mammals

摘要：

@@ Dear Editor,Histone methylation is a dynamic process that plays important roles in gene transcription regulation,and a number of enzymes have been shown to catalyze the removal of methyl marks”1”.Shi et al.(2004)identified one of the amino oxidases,lysine-specific demetbylase 1(LSD1),as the first specific demethylase for both mono(me)and dimethylation(me2)of H3K4 and H3K9 in humans”2”.Subsequently,a total of 27 JmjC-domaincontaining proteins have been discovered within the human genome,and 15 of them exhibit demethylation activities for specific lysines in the H3 tail”1”.

机标关键词：transcription regulation、dynamic process、human genome、activities、total、plays

所属期刊栏目：20

分类号：Q2(细胞生物学)

资助基金：the National Basic Research Program of China2005CB121000;the National High-Tech R&D Program2006AA10A119;the National Natural Science Foundation of China30825007;30870337

在线出版日期：2010-11-15（万方平台首次上网日期，不代表论文的发表时间）

页码：1079-1082