A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length

摘要：

@@ Dear Editor,Both the fission yeast Schizosaccharomyces pombe and the budding yeast Saccharomyces cerevisiae are popular model organisms, and studies using these models have provided many informative clues for solving fundamental biological questions ”1”, such as DNA replication,cell cycle regulation and gene transcription. Since the completion of genome sequencing of these fungi ”2, 3”,systematic genetic modification, e.g. gene deletion, has become possible, and genome-wide phenotypic screening for gene function has been widely carried out. For example, Askree et al. and Gatbonton et al. examined the telomere-length change in about 4 800 non-essential gene deletion mutants of S. cerevisiae, and found that about 250 genes are involved in telomere-length regulation.

机标关键词：mutants、gene deletion、Schizosaccharomyces pombe、Saccharomyces cerevisiae、regulation、genetic modification、completion、provided、function、studies、model、found、cell、DNA

所属期刊栏目：20

分类号：Q2(细胞生物学)

资助基金：This work was supportedNSFC30770453;funding from the Ministry of Science and Technology to LLD

在线出版日期：2010-11-23（万方平台首次上网日期，不代表论文的发表时间）

页码：963-965