Embracing the complexity of pre-mRNA splicing
@@ Pre-mRNA splicing is a fundamental process required for the expression of most metazoan genes. It is carried out by the spliceosome, which catalyzes the removal of non-coding intronic sequences to assemble exons into mature mRNAs prior to export and translation.Defects in splicing lead to many human genetic diseases ”1”, and splicing mutations in a number of genes involved in growth control have been implicated in multiple types of cancer.
genetic diseases、growth control、non-coding、required、multiple、mRNAs、human
20
Q2(细胞生物学)
2010-11-23(万方平台首次上网日期,不代表论文的发表时间)
866-868