MYC-microRNA-9-metastasis connection in breast cancer

摘要：

@@ Metastasis accounts for more than 90% of cancer patients” mortality. The metastatic process involves multiple steps ”1”. Initially, cancer cells from the primary tumor invade adjacent stroma. To acquire this capacity, cells undergo a process called epithelial-mesenchymal transition (EMT), in which cells in response to signals from the surrounding stroma, undergo a switch between cell phenotypes and acquire mesenchymal properties and show reduced intercellular adhesion, allowing cells to become motile. Then cells enter systemic circulation, either through the blood or lymph, and finally extravasate into the parenchyma of distant tissues, where they form micrometastasis and proliferate to form secondary tumors ”2”.

机标关键词：cells、mesenchymal、cancer patients、multiple、form、adhesion、EMT

所属期刊栏目：20

分类号：Q2(细胞生物学)

在线出版日期：2010-07-12（万方平台首次上网日期，不代表论文的发表时间）

页码：603-604