Palmitate impairs cytokinesis associated with RhoA inhibition
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@@ Dear Editor,Excess fatty acid accumulation in non-adipose tissues results in lipotoxicity, which has been implicated in the pathogenesis of metabolic diseases such as obesity and diabetes ”1”. A number of tissue culture systems have been used to study lipotoxicity by supplementation of culture media with palmitate, which is a major saturated free fatty acid in human plasma and has been reported to induce apoptosis in various cell types ”2”. Here we report that palmitate causes formation of binucleate cells as a consequence of cytokinetic impairment. Our results reveal a novel toxic effect of palmitate on cell division and extend the implication of lipotoxicity to cytokinetic failure.
科技部科研项目2006CB503900;2006CB9107031;国家自然科学基金30821065;a grant from the Knowledge Innovation Program of the Chinese Academy of SciencesKSCX1YW-02;a grant from Science and Technology Commission of Shanghai Municipality07dz05907