Mad revival of cancer
@@ Aneuploidy (wrong numbers of chromosomes) is a hallmark of cancer cells and arises from chromosome missegregation in mitosis. To prevent aneuploidy, cells employ surveillance systems to monitor mitosis. The spindle checkpoint (also known as the mitotic checkpoint) is one such surveillance system conserved from yeast to man ”1, 2”. During each mitosis, this check-point detects aberrant kinetochore-microtubule attachments, inhibits the anaphase-promoting complex or cy-closome (APC/C), stabilizes cyclin B1 and securin, and delays anaphase onset until all sister chromatids reach proper microtubule attachment. Mad2 is a criti-cal player of the spindle checkpoint and contributes to the inhibition of APC/C directly ”3”.
mitotic checkpoint、surveillance systems、cells、cyclin B1、complex、player、During、reach、Mad2、man
20
Q2(细胞生物学)
2010-05-26(万方平台首次上网日期,不代表论文的发表时间)
共3页
394-396