Mcl1 becomes ubiquitin-ous:new opportunities to antagonize a pro-survival protein
@@ Cancer remains a major cause of human mortality.The greatest barrier to cure is resistance to conventional medi-cal treatments. Therapy resistance arises through clonal evolution driven by ge-nomic instability, fostered by selection as therapy-sensitive cells are eradicated.Such resistance has been attributed to al-terations in numerous cellular pathways, yet many ultimately impact the process of mitochondrial apoptosis.
Mcl1、conventional、remains、impact、major、human、cells
20
Q2(细胞生物学)
2010-05-26(万方平台首次上网日期,不代表论文的发表时间)
共3页
391-393