Activation of JNK signaling links IgI mutations to disruption of the cell polarity and epithelial organization in Drosophila imaginal discs

摘要：

@@ Dear Editor, Identification of Drosophila melanogaster as a model organism for cancer research has facilitated the exploration of human tumor malignancy. In Drosophila, lossof-function mutations in the neoplastic tumor suppressor genes (nTSGs) lethal(2)giant larvae (lgl), discs large (dlg) or scribble (scrib) cause a malignant tumor-like phenotype characteristic of disrupted cell polarity and overgrowth in epithelial tissues such as imaginal discs ”1”.

机标关键词：cell、Drosophila melanogaster、tumor suppressor genes、exploration、research、model、human、dlg

所属期刊栏目：20

分类号：Q2(细胞生物学)

资助基金：国家自然科学基金30470890;科技部科研项目2007CB914504;2007CB947301;the Shanghai Pujiang Program05PJ14075;上海市学科建设项目B205

在线出版日期：2010-04-13（万方平台首次上网日期，不代表论文的发表时间）

页数：共4页

页码：242-245