Inhibition of cytokinesis by overexpression of NudCL that is localized to the centrosome and midbody

摘要：

@@ Dear Editor,
Cytokinesis is the process by which a single cell divides into two physically distinct daughter cells;however,the molecular details of this fundamental process remain largely unknown [1].In animal cells,cytokinesis usually consists of four stages:selection of the cleavage site,assembly of the cleavage furrow,ingression of the cleavage furrow,and abscission of the cell [1,2].At anaphase,the spindle midzone microtubules are bundled at their overlapping plus ends and the cleavage furrow has ingressed substantially.In telophase,after the cleavage furrow ingression,the midzone becomes narrow and tightly packed,which forms a dense structure known as the midbody.A large number of proteins are recruited to the midbody during cytokinesis.The midbody concentrates proteins that are associated with vesicular transport,thereby leading to abscission at a site that is adjacent to the midbody [3].During this process,the central spindle microtubules and the proteins localized at the midbody are essential for successful cytokinesis [1].

所属期刊栏目：19

资助基金：National Natural Science Foundation of China30671070 and 30771107;Ministry of Science and Technology of China2007CB914500;Ministry of Education of ChinaNCET-06-0530;Natural Science Foundation of Zhejiang Province,ChinaR205291,Y206103,and 2007R1032010103

在线出版日期：2009-12-15（万方平台首次上网日期，不代表论文的发表时间）

页数：共4页

页码：1305-1308