The Krüppel traffic report: Cooperative signals direct KLF8 nuclear transport
@@ The Krüppel-like transcription fac-tor (KLF) family consists of 17 dis-tinct family members involved in the regulation of diverse cellular processes including differentiation, cell prolifera-tion, growth-related signal transduction, angiogenesis and apoptosis (recently reviewed in ”1”). In addition to their currently known biologic roles, the discovery that at least one member of the family, KLF6, can be alternatively spliced into biologically active isoforms with antagonistic functions and a dis-tinct subcellular localization pattern ”2”, highlights the fact that nuclear-cytoplasmic shuttling of KLF proteins may represent an additional layer of functional regulation and the possibility of an even more diverse and completely unexplored role for KLF family mem-bers in both health and disease.
subcellular localization、family、regulation、signal transduction、processes、KLF、addition、active、fact
19
Q2(细胞生物学)
2009-10-23(万方平台首次上网日期,不代表论文的发表时间)
共3页
1041-1043