The saga of prion: to cut or not to cut

摘要：

@@ Transmissible Spongiform Enceph-aiopathies (TSE), commonly referred to as prion diseases, are a group of rare, infectious and fatal neurodegenerative diseases in mammals ”1”. All prion diseases are thought to share a common pathogenic mechanism, which is based on the conversion of the normal cellu-lar prion, PrPC, into the infectious and pathogenic scrapie prion protein, PrPSc ”2, 3”. The accumulation ofPrPSc in the CNS is then thought to impair function, induce structural damage, and cause disease. In addition to gain of toxic function, loss of normal PrPC function, a consequence of conversion to PrPSc may also contribute to pathogenesis ”4”.

机标关键词：prion protein、neurodegenerative diseases、function、structural damage、thought、addition、based、loss、TSE、CNS

所属期刊栏目：19

分类号：Q2(细胞生物学)

在线出版日期：2009-10-23（万方平台首次上网日期，不代表论文的发表时间）

页数：共2页

页码：1039-1040