Isolation and characterization of liver epithelial progenitor cells from normal adult rhesus monkeys (Macaca mulatta)

摘要：

@@ Dear Editor,Based on their ability to proliferate and the capacity to differentiate into specific cell types, hepatic progenitor/stem cells (HPCs) from adult human liver may have potential therapeutic effects on end-stage liver failure. In addition, adult HPCs have a reduced risk of teratoma formation and are not subject to the same ethical issues as fetal HPCs or embryonic stem cells ”1”. The HPCs from rhesus monkeys are relevant because they may serve as a valuable preclinical model for assessment of cell therapy in humans. To date, there are no reports of HPCs or liver epithelial progenitor cells (LEPCs) isolated from normal adult rhesus monkey although a few studies in other species were reported ”2, 3”. We report here for the first time the successful isolation of rhesus monkey LEPCs (mLEPCs) from normal adult livers (n=12).

机标关键词：rhesus monkey、embryonic stem cells、therapeutic effects、progenitor cells、liver failure、human liver

所属期刊栏目：19

分类号：Q2(细胞生物学)

资助基金：国家高技术研究发展计划863计划2005AA219010;2006AA02A116;国家重点基础研究发展规划973计划2006CB707505;2007CB947701;The Chinese Academy of SciencesKSCX1-YWR-47;KSCX1-05-02;国家自然科学基金30700159;30570906

在线出版日期：2009-03-31（万方平台首次上网日期，不代表论文的发表时间）

页数：共3页

页码：268-270