Mechanisms of p53-mediated mitochondrial membrane permeabilization
@@ The p53 protein is mutated or inactivated in more than 50% of human cancers, underscoring its cardinal importance as an oncosuppressor, p53 is expressed in all nucleated cells and can be activated by a plethora of post-transcriptional modifications (in particular by the phosphorylation of critical serine residues), as well as by the inhibition of its degradation (mainly mediated by the E3 ubiquitin ligase MDM2).
human cancers
18
Q2(细胞生物学)
2008-09-01(万方平台首次上网日期,不代表论文的发表时间)
共3页
708-710