PanK4 inhibits pancreatic β-cell apoptosis by decreasing the transcriptional level of pro-caspase-9
@@ Dear Editor:Coenzyme A(CoA)is a primary and predominant acyl group carrier involved in a wide variety of important biochemical processes.The CoA biosynthetic pathway is composed of five enzymatic steps,of which Pantothenate kinase(PanK)is a key regulatory enzyme.The multiple isoforms of PanK are encoded by four difierent genes”1,2”.In our previous studies of SNP markers by genotyping the case-controlled DNAs,we found that one SNP within the hPANK4 gene on chromosome 1 was associated with type 2diabetes”3-5”.We subsequently showed that rat PanK4 (rPanK4)was up-regulated when rats were challenged by high concentration ofglucose”6”.M2-type pyruvate kinase (Pkm2)was found,both in vitro and in vivo,to be associated with rPanK4”7”.
pyruvate kinase、in vitro
17
Q2(细胞生物学)
2008-05-28(万方平台首次上网日期,不代表论文的发表时间)
共3页
966-968