Direct generation of ES-like cells from unmodified mouse embryonic fibroblasts by Oct4/Sox2/Myc/KIf4

摘要：

@@ Dear Editor:The demonstration that four transcription factors,Oct4/Sox2/Myc/Klf4,can reprogram fibroblasts into ES-like cells or induced pluripotent stem cells(iPS cells)has generated tremendous jnterests not only in the field of stem cell biology,but also those related fields such as developmental biology and regenerative medicine”1-5”.The advance has greatly improved the prospects of generating patient specific pluripotent stem cells for therapeutic purposes without therapeutic cloning,an approach with formidable technical as well as ethical challenges.The conceptual breakthrough of the iPS strategy is quite obvious,demonstrating for the first time that the reprogrammmg of somatic nuclei can be achieved through a rational combination of transcription factors with defined regulatory activities,in contrast to the ill defined reprogramming power of unfertilized eggs.

机标关键词：transcription factors、stem cells

所属期刊栏目：17

分类号：Q2(细胞生物学)

在线出版日期：2008-05-28（万方平台首次上网日期，不代表论文的发表时间）

页数：共4页

页码：959-962