p27:tumor suppressor and oncogene…?
@@ The p27kip1 protein was initially identified due to itsability to bind and inhibit cyclin/cdk2 complexes leadingto an arrest in the G1-phase of the cell cycle.In line withthe cyclin kinase inhibitory function of p27,knockoutmice show a 30%increase in body size and a higher cyclinkinase activity in thymocytes leading to an acceleratedpassage through the cell cycle.The generation of p27knockout mice helped to formally establish p27 functionas a tumor suppressor protein.
cell cycle、tumor suppressor、body size
17
Q2(细胞生物学)
2008-05-28(万方平台首次上网日期,不代表论文的发表时间)
共2页
832-833