Deficiency of DNA fragmentation factor 45 results in reduced oocyte apoptosis in response to doxorubicin

摘要：

@@ Apoptosis plays a prominent role in ovarian development and function ”1-4”. During follicle development, the vast majority of follicles undergo atresia as a consequence of apoptosis of constituent oocyte or follicular cells, or both, failing to complete the maturation process. Atresia occurs at all stages of follicular development during the growth and development of follicles. Atresia of the primordial and primary follicles is initiated by oocyte apoptosis, followed by the death of the granulosa cells ”1-4”. In comparison, the reduction of the large number of growing follicles to a single ovulatory follicle is achieved primarily by the cell death of granulosa cells ”1-4”. Members of the Bcl-2 and caspase families play important roles in the regulation of ovarian cell death, both in follicle development and in response to chemotherapeutic agents ”5”.

机标关键词：chemotherapeutic agents、growth and development、follicular development、cell death、follicular cells

所属期刊栏目：17

分类号：Q2(细胞生物学)

资助基金：Department of Defense Ovarian Cancer Research Program,JZ

在线出版日期：2008-05-28（万方平台首次上网日期，不代表论文的发表时间）

页数：共2页

页码：735-736