国家自然科学基金30971473,31171317,31271375,31271450;江西省自然科学基金2010GZN0141;江西省卫生厅科技计划20092042,20092043;the National Natural Science Foundation of China30971473,31171317,31271375,31271450;by the Natural Science Foundation of Jiangxi Province2010GZN0141;by the Science and Technology Project of Health Department of Jiangxi Province20092042,20092043