国家自然科学基金青年基金项目31500260;湖北省卫计委中医药科研重点项目2012Z-Y27;湖北中医药大学教育部重点实验室科研启动项目5114000914.This work was supported by grants from the National Natural Science Foundation for Young Scientists of China31500260;the Traditional Chinese Medicine Scientific Research Key Project of Hubei Provincial Health and Family Planning Commission2012Z-Y27;the Initial Founding of Key Laboratory of Education Ministry at the Hubei University of Chinese Medicine5114000914