国家自然科学基金81100506;重庆市卫生计生委医学科研项目2017MSXM047;全国医学专业学位研究生教育委员会课题 B2-20170302-13 Fund program:National Natural Science Foundation of China81100506;Chongqing Municipal Health and Fami-ly Planning Commission Medical Research Project2017MSXM047;National Medical Professional Degree Graduate Education CommitteeB2-20170302-13