Free Fatty Acids Induce Pyroptosis in Pancreatic β-Cells
Dear Editor,Pyroptosis as a new mechanism of programmed cell death is different from the other two important programmed cell death pathways,apoptosis and necrosis.Apoptosis is a prototype of programmed cell death mediated by activation of the apoptotic caspases,which include caspase-2,-3,-6,-7,-8 and-9”1”.In the early process of apoptosis,cell exhibits shrinkage and pyknosis.Pyknosis is the result of chromatin condensation and this is the most characteristic feature of apoptosis.Finally,cells are fragmented into apoptotic bodies that are usually engulfed by surrounding macrophages,leading to the noninflammatory nature of the cell death”2”.In contrast to apoptosis,necrosis is triggered by activation of receptor-interacting protein kinase-1 (RIPK1) and RIPK3.RIPK3 phosphorylates the pseudokinase mixed lineage kinase domain-like (MLKL),causing it to translocate to the plasma membrane to induce cell permeabilization,swelling and lysis”3”.
45
We would like to thank the Center of Biological Imaging CBI at the Institute of Biophysics,Chinese Academy of Science,in particular,TENG Yan for her technical support with the confocal and real-time lapse imaging.We particularly thank SHAO Feng laboratory in National Institute of Biological Science NIBS for providing GSDMA antibody.This work was supported by a grant from The National Natural Science Foundation of China 31400703
2018-06-01（万方平台首次上网日期，不代表论文的发表时间）
共4页
375-378
