PLK1is a Novel Partner for DNA Endonuclease CtIP

摘要：

Dear Editor,DNA double-strand breaks caused by ionizing radiation are the most severe DNA damage types.If not being timely or correctly repaired,cells will undergo apoptosis or gene mutation and subsequent genomic instability”1-2”.For double-strand breaks,there are two main repair pathway in cells,namely homologous recombination and non-homologous end-joining ”3-4”.Homologous recombination repair utilizes homologous fragments of sister chromosomes,so that damaged DNA can be repaired more precisely.Homologous recombination repair mainly acts during the S/G2 phase of the cell cycle.

机标关键词：homologous recombination、ionizing radiation、gene mutation、DNA damage、cell cycle

所属期刊栏目：44

分类号：R39;S85

资助基金：the grants from The National Basic Research Program of China2015CB910601;The National Natural Science Foundation of China 31370843,31500681 to PK Zhou and The National Natural Science Foundation of China 31570853,81602799 to T Ma

在线出版日期：2017-05-23（万方平台首次上网日期，不代表论文的发表时间）

页数：共4页

页码：357-360