This work was supported by grants from The National Natural Science Foundation of China 81400790,81061120527,81370445,81472408,Funding from National Department Public Benefit Research Foundation by Ministry of Health P.R.China 201302008,12th 5 Year National Program from the Ministry of Scientific Technology 2012BAI10B01.国家自然科学基金81400790,81061120527,81370445,81472408,卫生部公益性研究基金201302008和国家科技部十二五支撑计划2012BAI10B01资助项目.