核糖糖基化引起仓鼠卵巢细胞GRP75变化
Dear Editor,Recently,type 2 diabetic patients were clinically observed to suffer from dysfunction not only in glucose metabolism,but also ribose ”1-2”.Ribose is rapidly reacted with protein ”34”,producing cytotoxic ribosylated products ”5”,whose progress is much faster than glucose ”6-7”.A 75 ku glucose regulated protein (GRP75) is generally recognized as a member of the heat shock protein 70 (HSP70) class of proteins,which is induced under conditions of low glucose and other nutritional and environmental stresses ”8-9” Administration of ribose induces a decrease in blood glucose ”10”,and thus changes in GRP75 should be studied when cells are exposed to ribose.
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This work was supported by NSFC31270868.
2014-12-17（万方平台首次上网日期，不代表论文的发表时间）
1191-1192
