grants from RG is an awardee of The Chinese Scholarship Council CSC.This work was partially supported by grants from The Canadian Institutes of Health Research to JH,The National Basic Research Program of China2011CB9107040;The National Natural Science Foundation of China 30973289,81272971.国家留学基金委高水平项目资助,加拿大卫生研究院CIHR研究基金资助项目,国家重点基础研究发展计划项目2011CB9107040;国家自然科学基金30973289,81272971