上海市卫生和计划生育委员会科研项目201540272;上海市青年科研项目20134Y165;上海市科学技术委员会科研项目16411968600,16ZR1433000.This work was supported by the Project of Scientific Research from Shanghai Municipal Commission of Health and Family Planning201540272;the Youth Project of Scientific Research from Shanghai20134Y165;the Project of Scientific Research from Science and Technology Commission of Shanghai Municipality16411968600,16ZR1433000