国家自然科学基金项目30800937;教育部留学回国人员科研启动基金;上海市公共卫生重点学科建设计划12GWZX0101.This work was supported by the National Natural Science Foundation of China30800937;the Scientific Research Foundation for the Returned Overseas Chinese Scholars,Ministry of Education,and the Key Discipline Constraction of Public Health of Shanghai12GWZX0101