Supported by Science and Technology Projects of Shenyang City F11-264-1-25,Science and Technology Projects of Liaoning Province 2013225049 and Scientific Foundation for Youth of Stomatology Hospital of China Medical University K101593-14-45.沈阳市科学技术计划项目F11-264-1-25;辽宁省科学技术计划项目2013225049;中国医科大学口腔医学院青年科研启动基金K101593-14-45