国家自然科学基金项目81001656,81341088,81273817;首都卫生发展科研专项首发2011-1001-06;北京市优秀人才培养资助项目2012D005018000010。 This study was supported by National Natural Science Foundation of China81001656,81341088,81273817;Cap-ital Medical Development Special Program2011-1001-06;Beijing Organization Department of Municipal Party Committee Project for Highly Talented Man2012D005018000010