四川省科技创新创业苗子工程重点项目2019JDRC0068;四川省卫生和计划生育委员会科研课题重点项目18ZD020;四川省干部保健科研课题川干研2018-802;四川省医学科研青年创新课题编号:Q16072 This study was supported by Science and Technology Innovation and Entrepreneurship Seedling Project of Sichuan Province Key Project NO. 2019JDRC0068 , Scientific Research Project of Health and Family Planning Commission of Sichuan Prov-ince Key Projec2018 -802;Project of Youth Innovation in Medical Research of Sichuan ProvinceQ16072