国家自然科学基金82170528;广东省自然科学基金2022A1515012254;广州市科技计划市校(院)联合资助项目202201020612;广州市临床特色技术项目2023C-TS48;National Natural Science Foundation of China82170528;Natural Science Foundation of Guangdong Province2022A1515012254;Guangzhou Municipal Science & Technology Joint Grant of Universities or Institutes202201020612;Guangzhou Municipal Project of Chinical Specialty Teclano logy2023C-TS48