Inhibition of ALDH2 by disulfiram leads to synthetic lethality via ROS strikes twice in ARID1A-deficient cholangiocarcinoma

摘要：

Synthetic lethality describes an interaction whereby the co-occurrence of two mutations leads to cell death but one mutation alone does not,which can be exploited for cancer therapeutics.1 Due to lacking effective non-surgical treatment and early clinical diagnosis markers,patients have high mortality and low overall survival rates in cholangiocarcinoma(CCA).2 Based on our previous predicted results in CCA(SLOAD,http://tmliang.cn/SL),ARID1A:ALDH2 is a pair gene with synthetic lethal.

机标关键词：disulfiram、inhibition、arid1a、aldh2、chol、ocar、olan、carcinoma、deficient、leads

所属期刊栏目：10

分类号：R733.71;R285.5;R978.16

在线出版日期：2023-05-26（万方平台首次上网日期，不代表论文的发表时间）

页数：共3页

页码：69-71