SEMA4D acts as a novel oligogenic pathogenic gene of idiopathic hypogonadotropic hypogonadism through the PlexinB1/MET/RND1/RHOA/RAF1/MAPK signaling axis

摘要：

Idiopathic hypogonadotropic hypogonadism(IHH)is a rare genetic disease with clinical and genetic heterogeneity.This study aimed to investigate a novel causal gene of IHH and a homozygous mutation(p.Ala515Val)in SEMA4D,and sought to determine the mechanism of SEMA4D promoting GnRH neurons migration.The detailed materials and methods were shown in Supplementary Methods.

机标关键词：sema4d、through、rhoa、mapk、axis、novel、acts、gene、hypogonadism、idiopathic

所属期刊栏目：10

分类号：R735.2;H3.1;R392.1

在线出版日期：2023-05-26（万方平台首次上网日期，不代表论文的发表时间）

页数：共4页

页码：65-68