国家自然科学基金项目81170830;国家“973”重点基础研究发展计划2013CB967001;北京市科技新星项目Z161100004916132;解放军总医院临床扶持基金2015FC-TSYS-2011Supported by the National Natural Science Foundation of China81170830;National "973" Program for Basic Science Research Development of China2013CB967001;Beijing Nova ProgramZ161100004916132