辽宁省教育厅科学技术研究项目L2010275;辽宁省自然科学基金2013022059;辽宁医学院青年科技启动基金Y2011Z010;This work was supported by the Science and Technology Research Foundation of the Education Department of Liaoning Province L2010275,the Natural Science Foundation of Liaoning Province 2013022059,and the Youth Science Foundation of Liaoning Medical University Y2011Z010