"十二五"国家科技支撑计划课题2012BAD17B03;山东省自主创新与成果转化专项2014ZZCX06205;山东省海洋经济创新发展区域示范项目《山东省海水养殖重要疾病高效专用药物产业化及示范推广》共同资助 [This work was supported by National Key Technology Research and Development Program of the Ministry of Science and Technology of China2012BAD17B03;Special Program for Independent Innovation and Achievements Transformation of Shandong Province2014ZZCX06205;Ocean Economic Innovation and Development Area Demonstration Project of Shandong Province "the Industrialization and Demonstration of High Efficiency and Special Medicine for Mariculture Diseases in Shandong Province"]