Probiotics supplementation in the management of hepatocellular carcinoma
Hepatocellular carcinoma (HCC, also known as primary liver cancer), is the fourth most frequent cancer and the third cause of deaths associated with cancer worldwide (1). HCC occurs in liver damaged tissue, due to chronic regenerative and inflammatory processes that contribute to the initiation and progression of the tumor (2). The main environmental factors associated with HCC are hepatotropic viral infection (hepatitis B and C, particularly), excessive consumption of alcohol, and exposure to aflatoxin through the diet. However, in the last 20 years, non-alcoholic fatty liver disease (NAFLD) has become a quickly emerging cause of end-stage liver disease worldwide. Typically, its hepatic injury starts with simple steatosis, which can progress to advanced stages such as non-alcoholic steatohepatitis (NASH), fibrosis and finally cirrhosis. Epidemiology studies report that about 3-15% of the obese patients with NASH progress to cirrhosis, and about 4-27% of NASH patients with cirrhosis present HCC (1).
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2020-04-03（万方平台首次上网日期，不代表论文的发表时间）
共3页
632-634
