Edible hybrid microbial-electronic sensors for bleeding detection and beyond
Introduction to edible electronics
Edible electronic devices are orally deployable electrified medical devices that have great potential to diagnose and treat many types of diseases. Interest in edible electronic devices has accelerated in recent years for several reasons. First, the role of gut health on overall health is becoming apparent. Microbiome composition influences metabolism, immunity, and cognitive function. The gut microbiome is also a valuable biomarker for distinguishing between healthy and diseased states. Distributed and longitudinal surveillance may could detect disorders such as inflammatory bowel disease (IBD), Crohn's disease, colorectal cancer, or bleeding. Second, the availability of computing platforms and genomic information are becoming more prevalent, cost-effective, and distributed. Miniaturized and low-cost electronics serve as a core technology for designing and fabricating edible electronic devices. Distributed computing platforms can provide a complementary monitoring network to interrogate ingestible medical devices in ambulatory patients. Third, there have been critically enabling advances in materials, non-conventional fabrication, and device integration. Here, Mimee et al. leverage many of these capabilities to create an edible electronic device to detect bleeding in clinically relevant animal models. The key innovation is the use of genetically engineered bacteria that transduce biochemical markers for bleeding into optical signals that can be measured, quantified, recorded, and communicated to external devices outside the body.
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The author acknowledges the financial support provided by the following organizations: the National Institutes of HealthR21NS095250;the Defense Advanced Research Projects AgencyD14AP00040;the National Science FoundationDMR1542196;the Carnegie Mellon University School of Engineering
2019-07-17（万方平台首次上网日期，不代表论文的发表时间）
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