Cabozantinib for advanced hepatocellular carcinoma
Introduction
Results of the phase Ⅲ CELESTIAL trial of cabozantinib were recently reported in the New England Journal of Medicine (1). Whereas all preceding clinical trials examining second-line agents ended in failure (2-7), the CELESTIAL trial succeeded, and cabozantinib has become the fourth molecular-targeted agent for hepatocellular carcinoma (HCC). This success was followed by another clinical trial of ramucirumab, the success of which was reported at the American Society of Clinical Oncology meeting in June 2018. As a result, two first-line agents, sorafenib and lenvatinib (8), and three second-line agents, regorafenib, cabozantinib, and ramucirumab, are now available for the treatment of HCC.
8
2019-07-17（万方平台首次上网日期，不代表论文的发表时间）
共4页
153-156
