The role of gut microbiota in immune checkpoint inhibitor therapy
It has been well established that the gut microbiota has a substantial influence on the host immune system. By crosstalk between specific microorganism-associated molecular patterns and the immune system, in addition to bacterial metabolic activity, gut microbiota regulates local or systemic inflammation (1). Recently, the composition of gut microbiota has been presumed to be one of the factors affecting the cancer-immune set point of cancer patients, which subsequently determines the efficacy of immune checkpoint inhibitor (ICI) treatment (2).
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We thank Dr. Tianye Li for the language editing assistance. Funding: This work was supported by the National Natural Science Foundation of China81572608, 81874120, 81672984;the Wuhan Science and Technology Bureau2017060201010170
2019-07-16(万方平台首次上网日期,不代表论文的发表时间)
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