Modelling western dietary habits in the mouse: easier said than done
The recent debate on the relative importance of environmental vs. intrinsic factors in the onset of malignancy has raised major concerns that the general public might conclude that cancer prevention programmes are not worthwhile. In their original report (1), Tomasetti and Vogelstein concluded that a majority of cancers can be explained by the high number of stem cell divisions in tissues with a high cell turn-over, due to generation of random mutations and their accumulation each time DNA replicates.
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The work of M. Schewe and M. Schmitt was made possible by grants from the Dutch Cancer FoundationKWF, EMCR 2012-5473;the World Cancer Research FundsWCRF, project no. 2014-1181;respectively. LA is supported by USPHS, NCI RO1 CA174432 and P30-13330
2019-07-18（万方平台首次上网日期，不代表论文的发表时间）
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138-140
