New players in non-alcoholic fatty liver disease induced carcinogenesis: lipid dysregulation impairs liver immune surveillance
Hepatocellular carcinoma (HCC), the primary cancer of the liver, is the fifth most common cancer and the second most common cause of cancer-related death worldwide with an expectancy to increase its incidence over the next 10–20 years (1). Although chronic viral infections [i.e., hepatitis B or C virus (HBV, HCV)], and chronic exposition to hepatotoxic factors such as toxins and alcohol are a major cause of HCC (2), in western countries and especially in the USA, obesity and dysregulated lipid metabolism are emerging as important non-viral factors associated with HCC (3,4).
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This work was partially supported by grants RF-2011-02346754 and GR-2011-02349580 from the Italian Ministry of Health
2019-07-18（万方平台首次上网日期，不代表论文的发表时间）
共4页
511-514
