Immune surveillance of liver cancer in non-alcoholic fatty liver disease: excess lipids cause CD4 T-cells loss and promote hepatocellular carcinoma development
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in industrialized countries with an increasing prevalence worldwide (1). Large-scale epidemiological studies have further associated NAFLD with various metabolic risk factors, mainly obesity and diabetes, and these conditions are clearly rising worldwide (2). Work of the last decades has shown that innate immune cells and inflammatory pathways play a central role in the pathogenesis of NAFLD (3). Patients with active inflammatory NAFLD, termed non-alcoholic steatohepatitis (NASH), are at particular risk for progressing to liver cirrhosis. Importantly, patients with NASH can develop hepatocellular carcinoma (HCC), even in non-cirrhotic livers (4).
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Both authors are supported by the German Research Foundation SFB/TRR 57. The authors thank Sabine Weiskirchen for preparing the figure
2019-07-17（万方平台首次上网日期，不代表论文的发表时间）
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433-437
