国家自然科学基金81300026;江苏省“科教强卫工程”医学青年人才QNRC2016747;苏州市临床医学中心Szzx201502.This work was supported by the National Natural Science Foundation81300026;the Youth Medical Talent of Jiangsu province Science and Education to Enhance Sanitary ProjectQNRC2016747;the Clinical Medicine Center of SuzhouSzzx201502;China